Photoreceptor differentiation

Vertebrate vision is mediated by the function of rod and cone photoreceptors, and each species generates and maintains ratios of rods to cones, and of specific cone subtypes. We are using the zebrafish embryo as a model system for probing the mechanisms that regulate the determination and differentiation of the different photoreceptor types.

Latest Publications

Plasticity of cone photoreceptors in adult zebrafish revealed by thyroid hormone exposure.

Farre AA, Thomas P, Huang J, Poulsen RA, Owusu Poku E, Stenkamp DL. Sci Rep. 2023 Sep 21;13(1):15697. doi: 10.1038/s41598-023-42686-x.

PMID: 37735192

Long wavelength-sensing cones of zebrafish retina exhibit multiple layers of transcriptional heterogeneity.

Farre AA, Sun C, Starostik MR, Hunter SS, English MA, Duncan A, Santhanam A, Shihabeddin E, O'Brien J, Swaroop A, Stenkamp DL. Front Cell Neurosci. 2023 Jul 14;17:1214084. doi: 10.3389/fncel.2023.1214084. eCollection 2023.

PMID: 37519633

Generating widespread and scalable retinal lesions in adult zebrafish by intraocular injection of ouabain.

Mitchell DM*, Stenkamp DL. 2023. Methods in Molecular Biology – Axon Regeneration: Methods and Protocols 2636:221-235

PMID: 36881303

Assessing rewiring of retinal circuitry by electroretinogram (ERG) after inner retinal lesion in adult zebrafish.

Barrett LM, Meighan PC, Mitchell DM, Varnum MD, Stenkamp DL. 2023. Methods in Molecular Biology – Axon Regeneration: Methods and Protocols 2636:421-435.

PMID: 36881314

Dynamic functional and structural remodeling during retinal regeneration in zebrafish.

Barrett LM, Mitchell DM, Meighan PC, Varnum MD, Stenkamp DL. Front Mol Neurosci. 2022 Nov 30;15:1070509. doi: 10.3389/fnmol.2022.1070509. eCollection 2022.

PMID: 36533135

Eye flukes (Diplostomum spp.) damage retinal tissue and may cause a regenerative response in wild threespine

stickleback fish.

Frey RA, Barrett LM, Parkin L, Blakeley B, Ålund M, Byford G, Euhus A, Tsarnas C, Boughman JW, Stenkamp DL.

Exp Eye Res. 2022 Oct 23:109298. doi: 10.1016/j.exer.2022.109298. Online ahead of print.

PMID: 36288754

An EvoDevo Study of Salmonid Visual Opsin Dynamics and Photopigment Spectral Sensitivity.

Eilertsen M, Davies WIL, Patel D, Barnes JE, Karlsen R, Mountford JK, Stenkamp DL, Patel JS, Helvik JV. Front Neuroanat. 2022 Jul 11;16:945344. doi: 10.3389/fnana.2022.945344. eCollection 2022.

PMID: 35899127

Evidence of regional specializations in regenerated zebrafish retina.

Stenkamp DL, Viall DD, Mitchell DM. Exp Eye Res. 2021 Oct 12:108789. doi: 10.1016/j.exer.2021.108789.

PMID: 34653519

Selective Requirements for Vascular Endothelial Cells and Circulating Factors in the Regulation of Retinal Neurogenesis.

Dhakal S, Rotem-Bamberger S, Sejd JR, Sebbagh M, Ronin N, Frey RA, Beitsch M, Batty M, Taler K, Blackerby JF, Inbal A, Stenkamp DL. Front Cell Dev Biol. 2021 Apr 8;9:628737. doi: 10.3389/fcell.2021.628737. eCollection 2021.

PMID: 33898420

Short-wavelength-sensitive 2 (Sws2) visual photopigment models combined with atomistic molecular simulations to predict spectral peaks of absorbance.

Patel D, Barnes JE, Davies WIL, Stenkamp DL, Patel JS. PLoS Comput Biol. 2020 Oct 21;16(10):e1008212. doi: 10.1371/journal.pcbi.1008212. eCollection 2020 Oct.

PMID: 33085657

Endocrine regulation of multichromatic color vision.

Mackin RD, Frey RA, Gutierrez C, Farre AA, Kawamura S, Mitchell DM, Stenkamp DL.

Proc Natl Acad Sci U S A. 2019 Aug 5. pii: 201904783. doi: 10.1073/pnas.1904783116.

PMID: 31383755

Rewiring the Regenerated Zebrafish Retina: Reemergence of Bipolar Neurons and Cone-Bipolar Circuitry Following an Inner Retinal Lesion.

McGinn TE, Galicia CA, Leoni DC, Partington N, Mitchell DM, Stenkamp DL.

Front Cell Dev Biol. 2019 Jun 6;7:95. doi: 10.3389/fcell.2019.00095. eCollection 2019.

PMID: 31245369

Vision using multiple distinct rod opsins in deep-sea fishes.

Musilova Z, Cortesi F, Matschiner M, Davies WIL, Patel JS, Stieb SM, de Busserolles F, Malmstrøm M, Tørresen OK, Brown CJ, Mountford JK, Hanel R, Stenkamp DL, Jakobsen KS, Carleton KL, Jentoft S, Marshall J,

Salzburger W.

Science. 2019 May 10;364(6440):588-592. doi: 10.1126/science.aav4632.

PMID: 31073066

Regeneration associated transcriptional signature of retinal microglia and macrophages.

Mitchell DM, Sun C, Hunter SS, New DD, Stenkamp DL.

Sci Rep. 2019 Mar 18;9(1):4768. doi: 10.1038/s41598-019-41298-8.

PMID: 30886241

Isolation of photoreceptors from mature, developing, and regenerated zebrafish retinas, and of microglia/macrophages from regenerating zebrafish retinas.

Sun C, Mitchell DM, Stenkamp DL.

Exp Eye Res. 2018 Aug 8;177:130-144. doi: 10.1016/j.exer.2018.08.002.

PMID: 30096325

Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina.

Galicia CA, Sukeena JM, Stenkamp DL, Fuerst PG.

Mol Vis. 2018 Jul 19;24:443-458. eCollection 2018.

PMID: 30078982

Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina.

Mitchell DM, Lovel AG, Stenkamp DL.

J Neuroinflammation. 2018 May 28;15(1):163. doi: 10.1186/s12974-018-1185-6.

PMID: 29804544

Transcripts within rod photoreceptors of the Zebrafish retina.

Sun C, Galicia C, Stenkamp DL.

BMC Genomics. 2018 Feb 8;19(1):127. doi: 10.1186/s12864-018-4499-y.

PMID:29422031

Predicting peak spectral sensitivities of vertebrate cone visual pigments using atomistic molecular simulations.

Patel JS, Brown CJ, Ytreberg FM, Stenkamp DL.

PLoS Comput Biol. 2018 Jan 24;14(1):e1005974. doi: 10.1371/journal.pcbi.1005974. eCollection 2018 Jan.

PMID:29364888

Restoration of Dendritic Complexity, Functional Connectivity, and Diversity of Regenerated Retinal Bipolar Neurons in Adult Zebrafish.

McGinn TE, Mitchell DM, Meighan PC, Partington N, Leoni DC, Jenkins CE, Varnum MD, Stenkamp DL.

J Neurosci. 2018 Jan 3;38(1):120-136. doi: 10.1523/JNEUROSCI.3444-16.2017.

PMID: 29133431

Characterization and Evolution of the Spotted Gar Retina.

Sukeena JM, Galicia CA, Wilson JD, McGinn T, Boughman JW, Robison BD, Postlethwait JH, Braasch I, Stenkamp DL, Fuerst PG.

J Exp Zool B Mol Dev Evol. 2016 Nov;326(7):403-421. doi: 10.1002/jez.b.22710.

PMID: 27862951

Development of the Vertebrate Eye and Retina.

Stenkamp DL.

Prog Mol Biol Transl Sci. 2015;134:397-414. doi: 10.1016/bs.pmbts.2015.06.006. Review.

PMID: 26310167

Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish.

Mitchell DM, Stevens CB, Frey RA, Hunter SS, Ashino R, Kawamura S, Stenkamp DL.

PLoS Genet. 2015 Aug 21;11(8):e1005483. doi: 10.1371/journal.pgen.1005483.

PMID: 26296154

Abnormal retinal development in Cloche mutant zebrafish.

Dhakal S, Stevens CB, Sebbagh M, Weiss O, Frey RA, Adamson S, Shelden EA, Inbal A, Stenkamp DL.

Dev Dyn. 2015 Nov;244(11):1439-55. doi: 10.1002/dvdy.24322.

PMID: 26283463

Retinal regeneration is facilitated by the presence of surviving neurons.

Sherpa T, Lankford T, McGinn TE, Hunter SS, Frey RA, Sun C, Ryan M, Robison BD, Stenkamp DL.

Dev Neurobiol. 2014 Sep;74(9):851-76. doi: 10.1002/dneu.22167.

PMID: 24488694

Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1.

Kashyap B, Pegorsch L, Frey RA, Sun C, Shelden EA, Stenkamp DL.

Reprod Toxicol. 2014 Jan;43:111-24. doi: 10.1016/j.reprotox.2013.12.002.

PMID: 24355176

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